Lower GI 2016

p16 – a promising biomarker in Anal Cancer

p16 – ink4a Chromosome 9p21 Inhibits entry into S phase of the cell cycle Binds CDK4/6 inhibiting formation of the cyclin-CDK4/6 complex HPV E7 protein binds Rb releasing E2F transcription factor leading to increased p16 expression p16 overexpression in anal cancer is a useful surrogate marker of high risk HPV infection !!!