Lower GI 2016

Human Papilloma Virus & Anal Carcinoma

• Vuyst et al ( 2009 ) – meta-analysis of 29 international studies between 1986 – 2008 Overall prevalence of HPV in AIN = 92.7 % ( 1280 cases ) Overall prevalence of HPV in anal carcinoma = 84.3 % ( 955 cases )

All types HPV 16 HPV18

Multiple types

AIN 1

91.5 % 37.2 % 21.3 % 54.4 %

AIN 2 & 3 93.9 % 59.8 % 17.4 %

SCC

84.3 % 73.4 % 5.2 % 6.8 %

• ? HPV more common in basaloid variant SCC ( > 95 % ) • ? HPV associated lower T stage & N stage at diagnosis