Lower GI 2016

SCC of the Anal Margin : Prognostic Factors

• Anal margin tumours have been reported to have both a better and worse prognosis than anal canal lesions – ACT 1 trial found no effect for LRF or OS. • Studies of prognostic factors specific to anal margin tumours are lacking and reported series are small

Chapet et al ( 2007 ) - 26 patients treated with primary EBRT or adjuvant RT after local excision : cancer specific survival related to age, tumour differentiation, T stage & N stage

N stage 5 yr CSS N0 93 % N1 67 % N2 33 %

T stage 5 yr CSS T1 100 % T2 92 % T3 37 % T4 0 %

Tumour diffn 5 yr CSS Well diffn 85 % Mod diffn 67 % Poor diffn 50 %

Khanfir et al ( 2008 ) – 45 patients with primary EBRT or adjuvant RT after local excision : no factors ( T stage, N stage, histological grade or age ) were predictive of loco-regional control