Basic Clinical Radiobiology 2017

Boosting in situ vaccination effect of RT

Herrera FG et al CA Cancer J Clin 2017

• Pharmacological activation of APCs  because immunomodulatory effects of RT are often not sufficient to trigger effective antitumor immune response due to potent immune suppression in tumor micro-environment and draining lymph node • E.g. agonists of stimulator receptor CD40 and to TLR