Basic Clinical Radiobiology 2017

Keratinocyte Growth Factor (Palifermin) Intervention with signaling

oral mucosa, mouse ulcer induction

16

14

12

10

8

10x3 Gy

6

n ≥ 5x10

4

2

0 ED50 of test irradiation [Gy]

Proliferation Differentiation Senescence Apoptosis Inflammation

Palifermin treatment protocol

Dörr et al., RTO ( 2005)