Basic Clinical Radiobiology 2017

Keratinocyte Growth Factor (Palifermin) Intervention with signaling

100

Grade 0

Grade 1

TBI + ChT Phase III randomised, placebo controlled

Grade 2

Grade 3

80

Grade 2

60

Grade 3

40

Grade 4

20

Grade 4

Incidence of mucositis [%]

0

Palifermin (rHuKGF) (n = 106) day -3, -2, -1 / 1, 2, 3

Placebo (n = 106)

Spielberger et al., NEJM 35, 2004, 2590-2598