Basic Clinical Radiobiology 2017

Radio-enhancement by dFdC of a human squamous cell carcinoma cell line (SQD9)

10 0

a b (Gy -1 ) (Gy -2 )

DMF=1.3

Rx 0.30 0.02 Rx + dFdC 0.38 0.04

DMF=1.3

10 -1

DMF=1.3

10 -2

10 -3 Rx alone dFdC (5 µM) for 3 h prior to Rx Surviving Fraction

10 -4

0 2 4 6 8 10 12 14

Absorbed dose (Gy)

ESTRO 2017

Rationales for combining chemotherapeutic agents and ionizing radiation

■ modulation of DNA/chromosome repair ■ regulation of tumor cell proliferation ■ enhancement of nucleoside analogue- induced apoptosis by IR ■ increased tumor cell re-oxygenation ■ increased tumor cell loss

ESTRO 2017