Basic Clinical Radiobiology 2017

EFFECT F-ara-A ON CHROMOSOME BREAK REPAIR AFTER SINGLE DOSE IRRADIATION (4 Gy) IN HUMAN LYMPHOCYTES

20 40 60 80 100 0 20 40 60 80 100 PERCENT OF INITIAL DAMAGE TIME AFTER IRRADIATION (min.) From Jayanth et al. RT alone F-ara-A (100 µM) 0.5 h prior to RT

ESTRO 2017

CELL CYCLE REDISTRIBUTION INDUCED BY FLUDARABINE (800 mg/kg) IN SA-NH TUMOR

0 h

3 h

6 h

12 h

BrdUrd CONTENT

15 h

18 h

24 h

36 h

DNA CONTENT

ESTRO 2017