Basic Clinical Radiobiology 2017

Combined chemo- and radiotherapy treatment: Cellular / molecular interaction

Antimetabolites

DNA damage Chromosome Cell

Apoptosis

induction repair

aberration Cycle

5-Fu MTX HU dFdC F-ara-A

- ? ?

-/+ ? -/+

- ?

+ ? + + +

? ? ? - -?

+ + +

- -

- -

ESTRO 2017

Combined chemo- and radiotherapy treatment: Cellular / molecular interaction

Alkylating agents

DNA damage Chromosome Cell Apoptosis induction repair aberration Cycle

Cis-platinum BCNU Cyclophosphamide

+? ? ?

+ + ?

? - -

- ? ?

? ? ?

ESTRO 2017