Basic Clinical Radiobiology 2017

Skin • Late radiation effects – mouse hind-limb

7

Two 10-fraction courses separated by 6 months Effect of re-irradiation more pronounced after more aggressive initial treatment Poorer retreatment tolerance than for early skin reactions

hind limb deformation

post 10 × 5 Gy

6

5

4

3

post 10 × 4 Gy

2

treatment alone

Severity (arbitrary units) 0 1

Brown & Probert Radiol 1975

3

4

5

6

7

Reirradiation dose per fraction (Gy)