Basic Clinical Radiobiology 2017

Lung • Retreatment tolerance of the mouse lung

pneumonitis

Initial dose <50% tolerance: full recovery , 2 months Higher initial doses: partial recovery , 3 months

14

treatment alone

12

post 6 Gy

10

post 8 Gy

Only applies for pneumonitis phase: retreatment tolerance fibrosis might be poorer

Retreatment-LD50 (Gy) 6 8

post 10 Gy

Terry Int J Radiat Oncol Biol Phys 1988

0

1

2

3

4

5

6

Time after first treatment (months)