Basic Clinical Radiobiology 2017

Kidney • Retreatment tolerance mouse kidney

Stewart Int J Radiat Oncol Biol Phys 1989

14

No recovery between 1 day and 6 months after

6.5 mo post 6 Gy

12

initial treatment Progression of

10

8

(subclinical) damage Retreatment tolerance decreases with time Extreme caution when re-irradiating kidneys!

2 wks post 6 Gy

6

4

Reduced kidney function 2

treatment alone

0

Reirradiation dose (Gy) 0 2 4 6 8 10 12 14 16