Basic Clinical Radiobiology 2017

Urinary bladder • Retreatment tolerance mouse bladder

20

No recovery between 1 day and 9 months after

Stewart Int J Radiat Oncol Biol Phys 1990

initial treatment Progression of

15

2F / 9 mo

(subclinical) damage results in shortening of latent times after retreatment Extreme caution when re-irradiating urinary bladder!

10

2F / 1 d

5

micturition frequency

2F / 3 mo

0

0

5

10 15 20 25 30 35

20 total dose (Gy)