Microsoft Word - LowLactose_ERP-Proposal-May2019

n Design and synthesis of precursors of hydrophobic drugs and novel drug delivery systems for subsequent radiolabelling n Introducing radio-labels n Evaluation of different formulations (hydrophobic drugs in micellar drug delivery systems) regarding their preparation, in vitro release, in vivo PK and tissue distribution for pharmaceutical applications

Education

09/2005 - 12/2009

PhD in the group of Prof. V. Wittmann, University of Konstanz “New methods for sequencing solid-phase bound cyclopeptides”

n Design, synthesis (SPPS) and modification (cyclisation, glycosylation, dye labelling, immobilisation etc.) and purification of peptides and combinatorial peptide libraries (OBOC). n Screening and characterisation of peptides including their structure-activity relationship with HPLC, MS, NMR and SPR n Responsible supervisor of the group’s Peptide Synthesizer (ABI433A) and HPLC system n Synthesis of fluorescently labelled phosphopeptides as substrates for microarray experiments (Cooperation with Department of Biology, Prof. C. Hauck) n Teaching fellow, “Organic Chemistry” for undergraduate chemistry students n Supervision of advanced student trainees in ”Combinatorial Chemistry” and “Chemical Biology of Carbohydrates” Diploma thesis: in the group of Prof. V. Wittmann in cooperation with Prof. M. Przybylski, University of Konstanz “De novo sequencing of single one-bead-one-compound peptide libraries by MALDI- FTICR-tandem mass spectrometry”

11/2004 - 08/2005

Studies in Chemistry at the University of Konstanz n Member of the Faculty Council of the Faculty of Chemistry n Tutor for Chemistry and Life Science students for organic chemistry

10/2000 - 08/2005

IT-Skills

Scientific software

n Experienced with subject-specific programs like ChemOffice, Xcalibur and Chromeleon (Thermo Science), MassLynx (Waters), Data-Analysis and TASQ (Bruker Daltonics), ChemStation (Agilent), GC/LC-Solution Software (Shimadzu), MestreNova and SciFinder. n Competent in all Microsoft Office packages including Excel, Word, PowerPoint, regularly used for academic and work projects.

other

Curriculum Vitae Dr. Angelika Semmler 2