Gynae BT 2017

PARCER trial (TMH), focus on bowel doses and morbidity

Phase III RCT of Postoperative Adjuvant Conventional Radiation (3DCRT) Vs. Image Guided Intensity Modulated Radiotherapy (IG-IMRT) for Reducing Late Bowel Toxicity in Cervical Interim Analysis

Chopra ASTRO, 2015

Interim analysis

•

• Significant less volume irradiated with IMRT after surgery

Bowel Dose

IMRT

3DCRT

P value

V15 Small Bowel ≥ 275 cc

8 (13.1%)

25 (44.6%)

<0.0001

V40 Small Bowel ≥ 150 cc

1 (1.6%)

26 (46.4%)

<0.0001

V15 Peritoneal Cavity ≥ 1200 cc

15 (24.5%)

24 (42.8%)

0.06

V40 Peritoneal Cavity ≥ 750 cc

1 (1.6%)

20 (35.7%)

<0.0001