AOAC Annual Meeting_AIMS

Hepatitis A Virus

• Severity of infection dependent upon mutations in IRES and/or the VP1/2A region • VP1-2A

• ↑mutations results in ↓severity • ↓mutations results in ↑severity

• IRES • Mutation associated with virulence with different genotypes • ↑IRES variability, decrease in severity and in some cases with other genotypes ↓IRES variability resulted in decrease severity