האגודה למלחמה בסרטן - במה - גיליון מס' 22 - ינואר 2018

ביטאון לעובדי בריאות בנושא מחלת הסרטן והשלכותיה במה

רשימת ספרות

1 Arnold D, Andre T, Bennouna J, et al. Bevacizumab (BEV) plus chemotherapy (CT) continued beyond first progression in patients with metastatic colorectal cancer (mCRC) previously treated with BEV plus CT: results of a randomized phase III intergroup study (TML study). J Clin Oncol. 2012;30(18) (suppl). [abstract]. Abstract CRA3503. 2. Van Cutsem E, et al. Intravenous aflibercept versus placebo in combination with irinotecan/5-FU (FOLFIRI) for second-line treatment of metastatic colorectal cancer (advanced cc): results of a multinational phase III trial (EFC10262-VELOUR). Ann Oncol. 2011;22(5). [abstract]. ESMO Abstract: O-0024. 3. Grothey, A, Sobrero AF, Siena S, et al. Results of a phase III randomized, double-blind, placebo- controlled, multicenter trial (CORRECT) of regorafenib plus best supportive care (BSC) versus placebo plus BSC in patients (pts) with metastatic colorectal cancer (mCRC) who have progressed after standard therapies. J Clin Oncol. 2012;30(4) (suppl). [abstract]. Abstract LBA385. 4. Peeters M, Price TJ, Cervantes A, et al. Randomized phase III study of panitumumab with fluorouracil, leucovorin, and irinotecan (FOLFIRI) compared with

8. Schwartzberg LS, Rivera F, Karthaus M, et al. PEAK: a randomized, multicenter phase II study of panitumumab plus modified fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) or bevacizumab plus mFOLFOX6 in patients with previously untreated, unresectable, wild- type KRAS exon 2 metastatic colorectal cancer. J Clin Oncol. 2014 Jul;32(21):2240-47. 9. Heinemann V, von Weikersthal LF, Decker T, et al. FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab as first-line treatment for patients with metastatic colorectal cancer (FIRE-3): a randomised, open-label, phase 3 trial. Lancet Oncol. 2014 Sep;15(10):1065–75. Epub 2014 Jul 31. 10. Siena S, Sartore-Bianchi A, Trusolino L, et al. Therapeutic dual inhibition of HER2 pathway for metastatic colorectal cancer (mCRC): the HERACLES trial. J Clin Oncol. 2015 Jan;33(3) (suppl). [abstract]. ASCO abstract 565. 11. Atreya CE, Van Cutsem E, Bendell JC, et al. Updated efficacy of the MEK inhibitor trametinib, BRAF inhibitor dabrafenib, and anti-EGFR antibody panitumumab in patients with BRAFV600E mutated metastatic colorectal cancer. J Clin Oncol. 2015 May 31;33(15) (suppl.) [abstract]. ASCO abstract 103.

FOLFIRI alone as second-line treatment in patients with metastatic colorectal cancer. J Clin Oncol. 2010 Nov;28(31):4706-13. 5. Douillard JY, Siena S, Cassidy J, et al. Randomized, phase III trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: the PRIME study. J Clin Oncol. 2010 Nov;28(31):4697-705. 6. Van Cutsem E, Köhne CH, Láng I, et al. Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer: updated analysis of overall survival according to tumor KRAS and BRAF mutation status. J Clin Oncol. 2011 May 20;29(15):2011-9. Epub 2011 Apr 18. 7. Venook AP, Niedzwiecki D, Lenz H-J, et al. CALGB/ SWOG 80405: phase III trial of irinotecan/5-FU/ leucovorin (FOLFIRI) or oxaliplatin/5-FU/leucovorin (mFOLFOX6) with bevacizumab (BV) or cetuximab (CET) for patients with KRAS wild-type untreated metastatic adenocarcinoma of the colon or rectum. J Clin Oncol. 2014;32(15) (suppl). [abstract]. ASCO Abstract LBA3.

Anti-angiogenesis with Avastin ® Colorectal Cancer

Avastin for mCRC patients is proven to prolong survival in 1 st line, 2 nd line and beyond 1 st progression 1,2,3

AVA-1712-V2-1971

1. Hurwitz H, et al. Bevacizumab plus Irinotecan, Fluorouracil, and Leucovorin for Metastatic Colorectal Cancer. N Engl J Med 2004;350:2335-42. 2. Giantonio et al. Bevacizumab in Combination With Oxaliplatin,Fluorouracil, and Leucovorin (FOLFOX4) for PreviouslyTreated Metastatic Colorectal Cancer ECOG study E3200. JCO 2007 3. Bennouna J, et al. Continuation of bevacizumab after first progression in metastatic colorectal cancer (ML18147): a randomised phase 3 trial Lancet Oncol 2013;14:29-37. References:

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