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Summary
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Small dose differences make a difference (clinically)
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Multi-criteria optimisation (MCO) – improved individualisation
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Keep talking – dialogue = 2 way conversation
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Protons
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Normal tissue response
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More data needed on normal tissue toxicity dose response
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Dose accumulation in normal tissues
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Biological variation in normal tissue sensitivity
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Could we convolve a
biological
measure of individual
normal tissue radiosensitivity with the
physical
dose plan