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Individual variation in normal tissue sensitivity
•
Variation in response harder to observe with mega-voltage beams
because of skin sparing
•
Could be exploited:
➢
To
avoid toxicity
in sensitive patients
▪
≤ 5% of patients
➢
To
dose escalate
resistant patients
▪
40% of patients - dose escalate up to ~15%
•
Other methods to measure normal tissue response are needed, to
produce more & better dose response data