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Normal tissue toxicities
•
Toxicity largely relates to
late normal tissue effects
➢
Tissue specific
•
Some
acute toxicities
also important
➢
Especially applies to concurrent chemo-RT
•
Very late effects
of second malignancy
➢
Difficult to estimate reliably
➢
For IMRT, need to balance risk from larger irradiated
volume against lower risk of organ damage
➢
Role for PBT in children