324 / 1161
Cardiac toxicity and mortality due to RT
•
7% increased risk on cardiac events per 1 Gy increase in mean heart dose
•
Increased mean heart dose: risk of cardiac disease mortality
•
Higher risk in patients treated with systemic therapy, e.g. chemotherapy,
trastuzumab
Darby NEJM 2013, Taylor Clinical Oncol 2015, Barlett Clin Oncol 2013, Taylor JCO 2017