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Motivation
•
accuracy of dose calculations
is crucial to
quality of treatment planning and
consequently to doses delivered to patients
•
evidence exists that dose differences on the
order of
7%
are clinically detectable.
Moreover, several studies have shown that 5%
changes in dose can result in 10%−20%
changes in tumor control probability (TCP) or
up to 20–30% changes in normal tissue
complication probabilities (NCTP)
•
The problem is:
➢
To model the treatment machine (
source
models
or
MC
)
➢
To model dose deposition in patient