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German Cancer Consortium (DKTK)
DOSE CONSTRAINTS FOR SBRT OF CENTRAL LC
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Maximum tolerated doses and optimum fractionation for mediastinal structures is
currently unknown
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Toxicity for SBRT delivered to central tumors is not well documented
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Serious doubts in the validity of available data, mostly coming from retrospective
series with small sample sizes
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Lacking, incomplete or inconsistent reporting on dose specification
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Questionable use of EqD2, α/ß-ratios, LQM estimates
Summary of current experiences in dose/ fraction - toxicity coherences after
SBRT to the mediastinal structures that lead to LungTech normal tissue constraints