814 / 1161
German Cancer Consortium (DKTK)
DOSE CONSTRAINTS:
LARGE VESSLES
Adebahr et al , BJR 2015
Great vessels
(aorta, vena cava sup. and inf., brachiocephalic veins)
(α/ß 3 Gy), potential side effects: hemoptysis and fatal bleeding
Reference
Number of
reported patients
(treated tumours)
Number
of
centres
Pro (p)-/
retro(r)-
spective
Results (max. point dose or dose/fractionation and EqD2 in Gy provided if possible)
Timmerman
(50)
70
1
p
Single cases of hemoptysis and fatal bleeding with varying SBRT regimens (s. bronchus)
Senthi (9)
(563)
20
°
r/p(4)
Single cases of hemoptysis and fatal bleeding with varying SBRT regimens (s. bronchus: Song
(51), Milano(62), Oshiro (63), Bral (36))
Canon et al.
(65)
75*
1
p
(s. bronchus)
Recommendations/NT constraints
Timmerman
(66)
maximum point dose: 37 Gy (1 fraction regime –
EqD2: 296 Gy
)
53 Gy (5 fraction regime –
EqD2: 144.2Gy
)
RTOG 0813 (56)
maximum point dose: 63 Gy (5 fraction regime -
EqD2: 196,6Gy
)
75 Gy (10 fractions regime
- EqD2: 157.5Gy
)
EORTC 22113-08113
no restrictions, but recording of DVH data for toxicity