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Conclusions
▪
Physical optimisation
using quadratic cost functions to
penalize the dose deviations seems practical, but may be too
optimistic in meeting the clinical objective
▪
Radiobiological optimisation
will become more trustworthy
by judicious use of more accurate dose-response models
▪
Physico-biological optimisation
can generate plans that
are clinically recognized and fulfill the dose and dose-volume
constraints based on clinical practice, while outperforming
physically optimised plans
Special acknowledgements to Aswin Hoffmann who kindly provided many slides