1156 / 1416
….. as
1 Gy photons ≠ 1 Gy Carbon Ions
further
validation of biophysical RBE models is urgently needed
…. should be considered an
experimental treatment
: role in
specific indications must be defined in prospective clincial trials
analysis of
normal tissue toxicity
, as well as
molecular responses
to high-LET beams need be addressed in clinical studies
could
risk
or
stratification factors
based on the individual
patient improve patient selection ?
Carbon Ions
increased “
dose conformality
”, and a reduced dose load to
normal tissues (a factor of 2-3
reduced “dose bath
”)
risk of normal tissue damage is higher due to
RBE uncertainties
and a
reduced fractionation (sparing) effect
Summary