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differen'al

response for

same LET s

less obvious

!

r

el

a

'

v

e

bi

ol

o

gi

c

al

ef

fe

ct

iv

e

n

e

ss

(

R

linear energy transfer (LET), keV/µm

Ando et al. 2009

13 brain tumor cell lines

4 normal fibroblast cell lines

clear differential effect correlated with LET

Is there a clinical beneficial differen'al effect

between normal and tumor 'ssues ?

(Carbon Ions)