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RADCOMP
CONSORTIUM
Aim 1: Insight into Biologic Mechanisms
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Specific Aim 1: To determine the early changes in multiple
biomarkers in patients undergoing RT, and how these
changes differ in proton versus photon therapy.
Hypothesis: Early increases in circulating biomarkers will
differ according to RT; photon therapy will result in a more
adverse biomarker profile.
Biologic Alteration
Biomarker
Inflammation
GDF-15, hsCRP
Microvascular Dysfunction PlGF
Oxidative Stress
MPO, PON, Aryl
Myocyte Injury
TnT
Myocyte Stress
NT-proBNP
Fibrosis
Galectin-3