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RADCOMP
CONSORTIUM
Aim 2: Insight into Functional Changes
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Specific Aim 2: To determine the early changes in
sensitive echo-derived measures in patients undergoing
RT, and how these changes differ in proton versus
photon therapy.
Hypothesis: Early abnormalities in measures of cardiac
size, function and mechanics will differ according to RT;
photon therapy will result in worse remodeling.
Functional Alteration
Echocardiographic Measure
Ventricular Structure
LV and RV size and mass
Systolic Function
LV and RV Strain, Strain rate,
Ejection fraction
Diastolic Function
e/a, e’, a’
Ventricular/Vascular Stiffness
Ea, Ees, Ea/Ees
Systolic/Diastolic Deformation
Twist, Torsion