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Hypofrac)ona)on

Dose escala)on

Architecture

Serial

Paralle

l

Organs-at-risk (low LET)

Liver, kidneys

Porta, extrahepatic bile ducts

Spinal cord,

stomach, intestine

α/β

Low

High

Conc chemo

Yes

No

CIRT hypofrac)ona)on or dose escala)on?