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31

Volume is important!

50

60

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90

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140

0 10 20 30 40 50 60 70 80 90 100 110

Volume HR CTV, cm

3

HR-CTV D90 optimized

Optimised

Violation of OAR constraint

Application of needles

11% needles

64% needles

K Tanderup et al, Radiother Oncol 2010