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2

Diarrhea

Flatulence

Incontinence (anal)

G0

569

(58.5%)

593

(61.0%)

839

(86.3%)

G1

317

(32.6%)

298

(30.7%)

109

(11.2%)

G2

72

(7.4%)

81

(8.3%)

20

(2.1%)

G3

13

(1.3%)

2

(0.2%)

G4

1

(0.1%)

2

(0.2%)

Number of patients 972 (missing 157)

Maximum incidence of single bowel symptoms, CTCAE

during all follow up