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BENEFIT FROM CONCOMITANT RADIOCHEMOTHERAPY
AUTHOR
RANDOMISATION ARMS
STAGE
LOCOREGIONAL
RECURRENCE
3 YEAR OVERALL
SURVIVAL
Keys
et al
N Engl J Med.
1999
RT + Cisplatin + HE
RT+ HE
Bulky
IB
9%
21%
RR 0.51 (95% CI)
83%
74%
(p=0.008)
Whitney
et al
J Clin Oncol. 1999
RT + Cis/5-FU
RT + HU
IIB,III,
IVA
24.9%
30.4%
RR 0.79 (90% CI)
67%
57%
(p=0.018)
Rose
et al
N Engl J Med.
1999
RT + Cisplatin
RT + Cis/5-FU+HU
RT + HU
IIB,III,
IVA
Not reported
65%
65%
47%
(p=0.004)
Morris
et al
N Engl J Med.
1999
RT + Cis/5-FU
RT (pelvis + paraaortal)
IB-IVA
(~70%
IB-IIB in
each
group)
19%
35%
RR 0.47 (95% CI)
75%
63%
(p=0.004)
Peters
et al
J Clin Oncol. 2000
HE + RT + Cis/5-FU
HE + RT
IA2,IB,
IIA
5.5%
17%
81%
71%
(p=0.007)
Pearcey
et al
J Clin Oncol. 2002
RT+Cisplatin
RT
IB-IVA
Not reported
69%
66%
(p=0.42)
SURVIVAL AND RECURRENCE AFTER CONCOMITANT
CHEMOTHERAPY AND RADIOTHERAPY FOR CANCER OF UTERINE
CERVIX: A SYSTEMATIC REVIEW AND META-ANALYSIS
Green et al. Lancet 2001;358:781-86
RT
RCHT
LOCAL RECURRENCE RATE
WAS SIGNIFICANTLY REDUCED BY CHEMORADIATION
OR 0.61, 95% CI 0.51-0.73, p< 0.0001
8%
4%
16%
9%
Toxicity Grade 3-4
Haematological
Gastrointestinal
47%
63%
PFS
40%
52%
OS
3656 patients (19 studies)