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Imaging Biomarkers: Challenges

Imaging biomarkers in clinical trials

Good QA & QC required

Technical standardization required

Minimum standards for measurement, analysis, & display

Central review

Baseline reproducibility should be part of study design

Leach M et al. Eur Radiol 2012;22(7):1451-64

Padhani AR et al. Neoplasia. 2009;11(2):102-25.

O’Connor J et al. Nat Reviews Clin Oncol 2016 (In press)