Molecular Imaging 2017

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Diffusion Response Markers
 Diffusion MRI used in
>60 therapy studies
 Therapy effects:
 Decrease in high b-
value signal intensity
 Increase in tumour ADC
≥30%
 Early response (14d)
assessment achievable
Afaq A et al. Cancer Imaging 2010; 10: S179-188;
Bains LJ et al. Cancer Imaging 2012; 12:395-402
ADC: 0.74 to 1.05 x10-3 mm2/s