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Safety/Toxicity/Dosage
Phase I
Drug effectiveness
Safety
Randomisation
Tested vs standard
treatment
Phase II
Phase III
Go/No go
Go/No go
Question: Is the agent
safe & is there biological
activity?
Question: Does the drug
work sufficiently well?
Question: How well does
the drug work compared
to what we have?
Clinical Trials of Novel Agents:
Targeted imaging