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Immune Response Criteria
Wolchok JD et al. Clin Cancer Res 2009;15(23):7412–20
Nishino M et al. Eur J Radiol 2015; 84: 1259–1268
CR
PR
SD
PD
Resolution of target
lesions & all nodes
<10 mm in short
axis
>30% decrease
from baseline
Neither PR not PD ≥20% increase
from the nadir
New lesions do not define progression
& measurements are included in TL; PD or
PR must be confirmed by 2 consecutive observations >4wks apart
iRC: Unidimensional simulating RECIST 1.1; Max 2/organ & 5 total
CR
PR
SD
PD
Resolution of target
lesions & all nodes
<10 mm in short
axis
>50% decrease
from baseline
Neither PR not PD ≥25% increase
from the nadir
iRC: Bidimensional; Max 5/organ; Up to 10 visceral & 5 cutaneous lesions