Molecular Imaging 2017

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Vascular Response Assessment
Effects measured by T1 DCE-MRI
Therapy Measured effect
Chemotherapy IAUGC, Ktrans
Radiation IAUGC, Ktrans initially, then
Anti-angiogenic agents IAUGC, Ktrans initially, then
Ablative therapy IAUGC, Ktrans
IAUGC = Initial area under the Gadolinium curve; Ktrans = transfer constant
Extent of changes depends on therapy evaluated & timing to therapy
Phase I/II trials