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Vascular Response Assessment
Effects measured by T1 DCE-MRI
Therapy
Measured effect
Chemotherapy
IAUGC, K
trans
Radiation
IAUGC, K
trans
initially, then
Anti-angiogenic agents
IAUGC, K
trans
initially, then
Ablative therapy
IAUGC, K
trans
IAUGC = Initial area under the Gadolinium curve; K
trans
= transfer constant
Extent of changes depends on therapy evaluated & timing to therapy
Phase I/II trials