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Clinical Implementation of DPBN:
Prescription function
• Dose prescription is different in each
tumor voxel
• Prescription function has to be
integrated into the optimisation process
during RT-planning
SUV A
[Bq/ml]
3.3
1.2
1.9
2.6
3585
1300
2060
2820
84.0 Gy
80.5 Gy
77.0 Gy
73.5 Gy
66.5 Gy
57.5 Gy
51.5 Gy
42.0 Gy
28.0 Gy
linear
sigmoid
PET voxel activity
Dose Escalation
Factor