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MR spectroscopic imaging for dose-painting in newly diagnosed GBM -
Take Home Message
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Predictive value of MR spectroscopy with CHO/NAA>2 is well-known and
of LAC/NAA> 0.4 was recently described .
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170 patients have been already included in SPECTRO GLIO , a prospective
multicentric clinical dose-painting trial MR spectroscopy volumes of
CHO/NAA > 2 comparing standard 60 Gy with SIB IMRT at 72 Gy
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From the ongoing SPECTRO GLIO trial, longitudinal spectroscopy, perfusion
and diffusion MRI studies will allow the confirmation and/or definition of
new Biological Target Volume(s) for further dose-painting trials
MR spectroscopic imaging for dose-painting
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