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The PROMIS study
576 men: MP-MRI followed by TRUS-& TPM-biopsy
408 (71%) had cancer; 230 (40%) clinically significant (G4+3)
Clinically significant cancer:
MP-MRI more SENSITIVE: 93% [95% CI 88-96%] vs TRUS-
biopsy, 48% [42-55%]; p<0·0001
MP-MRI LESS specific: 41% [36-46%] for MP-MRI vs 96%,
[94-98%] for TRUS-biopsy; p<0·0001)
44 (5·9%) of 740 patients reported serious adverse events,
including 8 cases of sepsis
Ahmed HU et al. PROMIS study group. Lancet 2017;389(10071):815-822
Kapoor J et al. Eur Urol. 2017 Feb 23. pii: S0302-2838(17)30103-3.