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Can ADC differentiate malignant from benign nodes?
Author, Yr
Pts
B values
Nodes
Findings: ADC
Surgery alone
Heijnen et al
2013
n=21 1.5T:
0,500,1000
Total: 212
Met: 16
NM: 1.04 ± 0.22; M: 1.15± 0.24 X10
-3
Cut off 1.07 X10
-3
: Sn 67%, Sp 60%, PPV
18%, NPV 93%
Cho et al
2013
n=34 1.5T: 0,1000 Total: 114
Met: 46
NM: 1.1 ± 0.22; M: 0.9± 0.15 X10
-3
Cut off 1 X10
-3
: Sn 78%, Sp 67%, PPV
61%, NPV 82%
Pre-operative chemoradiation therapy
Lambregts et al
2011
n=30 1.5T:
0,500,1000
Total:222
Met: 34
NM: 1.19 ± 0.27; M: 1.43 ± 0.38 X10
-3
Cut off 1.25 X10
-3
: Sn 53%, Sp 82%, PPV
35%, NPV 91%
Kim et al
2014
n=59 1.5T: 0,1000 Total: 115
Met: 29
NM: 1.13 ± 0.23; M: 1.36 ± 0.27 X10
-3
Cut off 1.25 X10
-3
: Sn 66%, Sp 72%, PPV
46%, NPV 87%
Heijnen LA et al. Eur Radiol 2013; 23(12): 3354-60; Cho EY et al. Eur J Radiol 2013;
82 (11): 662-8; Lambregts DM et al. Eur Radiol 2011; 21 (12): 2567-74;
Kim SH et al. Acta Radiol 2014; Nov 25 Epub