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Tumor with complex infiltration
Histological series : tumors 2 cm around CE
CTV = CE + 2cm
What is the real tumor extension ?
95% relapse within the fields : how can we define resistant regions ?
Standard Brain MRI
T2/FLAIR reflects edema and micoscopic invasion and
overestimates tumoral volume
T1 gado reflects the rupture of hematomeningeal barrier
and underestimates tumoral volume