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Tumor with complex infiltration

Histological series : tumors 2 cm around CE

CTV = CE + 2cm

What is the real tumor extension ?

95% relapse within the fields : how can we define resistant regions ?

Standard Brain MRI

T2/FLAIR reflects edema and micoscopic invasion and

overestimates tumoral volume

T1 gado reflects the rupture of hematomeningeal barrier

and underestimates tumoral volume