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Depicting the Biological Target Volume=

BTV

Local relapses can be due to cellular or micro-

environment clusters that resist to standard

homogeneous dose.

Metabolic imaging can help define radioresistant

clusters

Biological Target Volume

New radiotherapy techniques allow a precise

targeting of BTV

Optimisation of radiotherapy can be performed with

Dose-painting

: delivering heterogenous dose guided

by metabolic imaging