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Take home message

Validated metabolic MR imaging for a further dose-painting trial

MRSI

DWI : no convincing evidence

PWI : no convincing evidence

Use of fMRI for balistic choices ? work in progress

Next step to implement these modalities in the

treatment process

Identify a reprodictive BTV based upon the metabolic imaging

Dosimetric studies of dose-escalation

Clinical trials of dose escalation !