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CLINICAL PROBLEM
•
Contrast enhancement on CT and MRI and hyperintensity
areas MRI are not always real measures of tumor
extension. Tumor cells are detected beyond the margins of
contrast enhancement, in the surrounding edema, and
even in the adjacent normal-appearing tissue.
•
After treatment, contrast enhancement and edema can be
treatment related and cannot be differentiated from
persistent tumor on CT or MRI.
•
(Traditional) CT and MRI give no information about the
biological properties of the tumor.
Limitation of CT and MRI