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Rationale for Using Amino Acids-PET/SPECT
for Tumor Tissue Detection in Gliomas
• High uptake in tumor cells mediated
by the L-/A-amino acid transport.
• Amino acids not taken up by normal
cortical gray matter.
• Good target-to-background
contrast, allowing better
characterization and differentiation
of tumor from normal cortical
tissue.
(Ishiwata 1993; Kanai 1998)
wildtype
BHK 21
transformed
BHK 21
Accumulation of alpha-amino-
isobutyrat (AIB) in-vitro