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GLIAA Study
Arm A (Experimental Intervention)
PTV definition according to FET-PET:
GTV = AA uptake PET
(CTV) = GTV + 3 mm,
(PTV) = CTV + 1-2mm
Arm B (Control Intervention)
PTV definition according to CET1-MRI:
GTV = CE in T1
(CTV) = GTV + 3 mm,
(PTV) = CTV + 1-2mm
High precision re-irradiation:
39 Gy; 3 Gy/d 5x/w
Oehlke O et al. (2016) Amino-acid PET versus MRI guided re-irradiation in patients with recurrent glioblastoma
multiforme (GLIAA) - protocol of a randomized phase II trial (NOA 10/ARO 2013-1). BMC Cancer 16:769