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Risk groups – Individual tumor characteristics:

Biopsies: at random - systematic

Chance of hitting tumor per biopsy=15-20%

Gl

l

d ibl

eason score: poor y repro uc e

Biopsy agreement with prostatectomy: (n=1670)

Gleason 5-6 undergrading: 35%

Gleason 8-10 overgrading: 35%

PSA

Suspected linear relation with amount of tumor cells

I li bl d t l

k

ft f l

iti

rre a e ue o ea age, o en a se pos ve

Conclusion: Literature contains probably higher Gleason scores too