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Risk groups – Individual tumor characteristics:
Biopsies: at random - systematic
Chance of hitting tumor per biopsy=15-20%
Gl
l
d ibl
eason score: poor y repro uc e
Biopsy agreement with prostatectomy: (n=1670)
–
Gleason 5-6 undergrading: 35%
–
Gleason 8-10 overgrading: 35%
PSA
–
Suspected linear relation with amount of tumor cells
I li bl d t l
k
ft f l
iti
–
rre a e ue o ea age, o en a se pos ve
Conclusion: Literature contains probably higher Gleason scores too