1276-1277 / 2001
Radiation proctitis Chr
‐
Histological findings
•
obliterative endarteritis of the small vessels in
intestinal wall characterizes chronic radiation
intestinal injury
•
Associated lymphoid atrophy, lymphatic dilati
fibrosis of the submucosal tissue are observed
•
The progressive vascular sclerosis leads to chr
ischemia of the overlying tissue, ultimately re
in mucosal atrophy
•
Scar tissue replaces the submucosal tissue, re
in further decrease in vascularity and contrac
the intestinal wall
•
Chronic mucosal ulceration may result in fistu
formation and hemorrhage
onic
the
on, and
onic
sulting
sulting
ture of
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